FACT SHEET: LIVER DISEASE
Liver disease can happen if AAT becomes stuck in the liver due to a genetic change that can change the shape of the AAT and it becomes stuck in the liver.
Liver disease can happen if AAT becomes stuck in the liver due to a genetic change that can change the shape of the AAT and it becomes stuck in the liver.
Liver Transplantation is an end-stage treatment to replace a diseased liver, and to extend life expectancy. Liver transplantation is a highly successful treatment.
About 10% of children will have severe Alpha-1 liver problems causing liver disease. Some PiZZ children will be born with liver disease or may develop it later in childhood.
Liver fibrosis (early-stage scarring) and cirrhosis (scarring) result from liver damage. These can be caused by trapped antitrypsin (polymer) in the liver.